反応 #432982

反応方程式

N-benzylmaleimide

2-chloroethylamine hydrochloride

triethylamine

→

1-Benzyl-3-(2-chloroethylamino)-pyrrolidine-2,5-dione

溶媒

—

petroleum ether

ethyl acetate

反応条件

後処理

1. 1
   その他are obtained

実験手順

74.8 g (0.4 mol) of N-benzylmaleimide are reacted with 58 g (0.5 mol) of 2-chloroethylamine hydrochloride and 50.5 g (0.5 mol) of triethylamine in accordance with the working instructions of Example Ia. After working up by chromatography, 81.6 g (77% of theory) of an oil with an RF value of 0.24 (on silica gel using ethyl acetate:petroleum ether=1:1) are obtained.

出典