反応 #432866

反応方程式

4-benzyloxybenzonitrile

THF

hydrogen chloride

→

methyl 4-benzyloxybenzimidate hydrochloride

溶媒

methanol

反応条件

後処理

1. 1
   ろ過The precipitate was filtered off
2. 2
   洗浄washed with diethyl ether
3. 3
   その他dried

実験手順

A solution of 560 mg of 4-benzyloxybenzonitrile in 16 ml of THF and 0.2 ml of methanol, cooled to 0° C., was saturated with hydrogen chloride and kept at 4° C. for 16 hours. The precipitate was filtered off, washed with diethyl ether and dried to give 357 mg of methyl 4-benzyloxybenzimidate hydrochloride, m.p. 179°-180° C.

出典