反応 #43271

反応方程式

ethyl (10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)acetate

(S)-7-iodomethyl-1,4-d ioxaspiro[4.4]nonane

methyl (S)-3-oxo-cyclopentanecarboxylate

5-methoxy-thiazolo[5,4-b]pyridin-2-ylamine

→

N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)-2-(10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-3-((R)-3-oxocyclopentyl)propionamide

反応条件

実験手順

Analogously to Example 1 and Example 36, ethyl (10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)acetate, (S)-7-iodomethyl-1,4-d ioxaspiro[4.4]nonane (prepared analogously to Example 40 from commercially available methyl (S)-3-oxo-cyclopentanecarboxylate) and 5-methoxy-thiazolo[5,4-b]pyridin-2-ylamine give N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)-2-(10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-3-((R)-3-oxocyclopentyl)propionamide.

出典