反応 #43185

反応方程式

3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

intermediate 1

3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

tert butylamine

→

tert-Butyl-[3-(2-chloro-pyrimidin-4-yl)-benzyl]-amine

収率 97.0%

反応条件

実験手順

3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde (intermediate 1) and tert butylamine were coupled by procedure B. The yield was 97%. LC-MS showed the product had the expected M+H+ of 276. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) 8.6 (d, 1H) 8.1 (s, 1H) 7.9 (d, 1H) 7.6 (d, 1H) 7.5 (m, 2H) 1.2 (s, 9H).

出典