反応 #431421

反応方程式

Water

Sodium hydride

benzyl alcohol

1,5-dibromopentane

→

5-benzyloxypentyl bromide

収率 100.9%

溶媒

dimethylformamide

反応条件

後処理

1. 1
   workup.STIRRINGThe mixture was stirred at room temperature for 1 hr
2. 2
   温度cooled
3. 3
   workup.STIRRINGby stirring at room temperature for 3 hr
4. 4
   抽出the mixture was extracted with ethyl acetate
5. 5
   洗浄The organic layer was washed with brine
6. 6
   その他dried
7. 7
   その他the solvent was evaporated under reduced pressure

実験手順

60% Sodium hydride (1.33 g) was suspended in dimethylformamide (40 ml), and benzyl alcohol (3 g) was added under ice-cooilng with stirring. The mixture was stirred at room temperature for 1 hr. The mixture was again ice-cooled, and 1,5-dibromopentane (6.4 g) was added, which was followed by stirring at room temperature for 3 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried and the solvent was evaporated under reduced pressure to give 7.2 g of 5-benzyloxypentyl bromide.

出典