反応 #43118

ord-147ea39c103e4009b1b074fb6096c15c

反応方程式

CC(C)(C)OC(=O)NCCCNCc1cccc(-c2ccnc(Cl)n2)c1
Intermediate 2
CC(C)(C)OC(=O)NCCCNCc1cccc(-c2ccnc(Cl)n2)c1
{3-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-propyl}-carbamic acid tert-butyl ester
CC(C)N
isopropylamine
→
CC(C)NCc1cccc(-c2ccnc(Cl)n2)c1
[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-isopropyl-amine

反応物

CC(C)(C)OC(=O)NCCCNCc1cccc(-c2ccnc(Cl)n2)c1
Intermediate 2
CC(C)(C)OC(=O)NCCCNCc1cccc(-c2ccnc(Cl)n2)c1
{3-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-propyl}-carbamic acid tert-butyl ester
CC(C)N
isopropylamine
—
262

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Intermediate 2 was coupled with isopropylamine following procedure B. LC-MS showed the product had the expected M+H+ of 262.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07732444B2uspto-grants-2010_06