反応 #43023

反応方程式

Intermediate 6

3-(2-Chloro-pyrimidin-4-yl)-phenylamine

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

→

3-[3-(2-Chloro-pyrimidin-4-yl)-phenylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester

収率 70.0%

反応条件

後処理

1. 1
   その他The product was purified on silica gel using 1:1 ethyl acetate

実験手順

Intermediate 6 was coupled with 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester following procedure J. The product was purified on silica gel using 1:1 ethyl acetate:hexanes as eluent. Yield: 70%. LC-MS showed the product had the expected M+H+ of 375.

出典