反応 #430112
ord-a287f31b9303459e8fd267ab8b600b01
反応条件
詳細条件
See reaction.notes.procedure_details.
実験手順
It has been found that, surprisingly, when neutralizing (S)-2-(6-methoxy-2-naphthyl)propionic acid having a chiral purity below 99% with less than a stoichiometric amount of aqueous sodium hydroxide solution to form naproxen sodium, it is possible to increase the chiral purity of the naproxen sodium to 99% or more by removing the water by use of a suitable organic solvent, or simply by distilling off water from an aqueous solution.