反応 #4297

反応方程式

2-chloroethylphenyl sulfone

methylamine

→

title compound

N-Methyl-2-(phenylsulfonyl)ethanamine

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他The solvent is removed in vacuo
2. 2
   その他the residue is partitioned between methylene chloride and dilute sodium hydroxide
3. 3
   抽出The methylene chloride solution is extracted with dilute sulfuric acid
4. 4
   抽出The acidic extract
5. 5
   抽出the basic solution is extracted with methylene chloride
6. 6
   乾燥The methylene chloride solution is dried over magnesium sulfate
7. 7
   その他the solvent is removed in vacuo

実験手順

A solution of 2-chloroethylphenyl sulfone and a large excess of methylamine (40% solution in water) in acetonitrile is stirred at room temperature overnight. The solvent is removed in vacuo and the residue is partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution is extracted with dilute sulfuric acid. The acidic extract is made basic with 50% sodium hydroxide and the basic solution is extracted with methylene chloride. The methylene chloride solution is dried over magnesium sulfate and the solvent is removed in vacuo to give the title compound.

出典