反応 #429628

反応方程式

7-amino-2-ethyl-3-methylbenzo[b]furan

2,6-dichlorobenzoyl chloride

triethylamine

→

7-(2,6-dichlorobenzoylamino)-2-ethyl-3-methylbenzo[b]furan

収率 35.8%

溶媒

1,2-dichloroethane

dichloromethane

反応条件

後処理

1. 1
   洗浄washed with diluted hydrochloric acid and brine
2. 2
   乾燥dried over sodium sulfate
3. 3
   その他evaporated in vacuo
4. 4
   その他to give a solid
5. 5
   その他The residue solid was crystallized from a mixture of ethanol (20 ml) and water (2 ml)

実験手順

A mixture of 7-amino-2-ethyl-3-methylbenzo[b]furan (858 mg), 2,6-dichlorobenzoyl chloride (1.23 g) and triethylamine (1.23 g) in 1,2-dichloroethane (17 ml) was stirred for 3 hours at 70° C. The mixture was diluted with dichloromethane, washed with diluted hydrochloric acid and brine, dried over sodium sulfate, and evaporated in vacuo to give a solid. The residue solid was crystallized from a mixture of ethanol (20 ml) and water (2 ml) to give 7-(2,6-dichlorobenzoylamino)-2-ethyl-3-methylbenzo[b]furan (610 mg).

出典