反応 #429356

反応方程式

ethyl bromide

magnesium

ethyl oxalate

1-bromo-2-(1-ethoxyethyl)oxymethylbenzene

→

ethyl 2-[2-{(1-ethoxyethyl)oxymethyl}phenyl]-2-oxoacetate

収率 68.4%

溶媒

THF

THF

water

THF

反応条件

後処理

1. 1
   その他prepared
2. 2
   workup.ADDITIONAfter completion of the addition
3. 3
   温度After cooling
4. 4
   workup.STIRRINGThen, the mixture was stirred at -50° to -60° C. for 1 hour
5. 5
   workup.ADDITIONwas added
6. 6
   抽出the mixture was extracted with ether (200 ml)
7. 7
   乾燥The extract was dried over anhydrous magnesium sulfate
8. 8
   濃縮concentrated under reduced pressure
9. 9
   その他The resulting residue was purified by silica gel chromatography (ethyl acetate/n-hexane)

実験手順

A mixed solution of 1-bromo-2-(1-ethoxyethyl)oxymethylbenzene (3.11 g, 0.012 mol) and dry THF (10 ml) was added dropwise at 50° to 60° C. over 25 minutes to a solution prepared by adding dry THF (2 ml) and ethyl bromide (0.2 ml) to magnesium (0.44 g, 0.018 mol) in a stream of nitrogen. After completion of the addition, the mixture was stirred at 50° to 60° C. for 1 hour and cooled to room temperature. After cooling, the mixture was added dropwise to a mixed solution of ethyl oxalate (2.63 g, 0.018 mol) and dry THF (30 ml) at below -50° C. over 15 minutes. Then, the mixture was stirred at -50° to -60° C. for 1 hour. After completion of the reaction, water (200 ml) was added, and the mixture was extracted with ether (200 ml). The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (ethyl acetate/n-hexane) to obtain ethyl 2-[2-{(1-ethoxyethyl)oxymethyl}phenyl]-2-oxoacetate (2.30 g, Yield: 68.4%) as a colorless oil.

出典