反応 #429355

反応方程式

3,4-dihydro-2H-pyrane

2-bromobenzyl alcohol

sodium bicarbonate

→

1-bromo-2-(2-tetrahydropyranyloxymethyl)benzene

収率 99.3%

溶媒

dichloromethane

反応条件

後処理

1. 1
   workup.STIRRINGAfter the resulting mixture was stirred at room temperature for 2 hours
2. 2
   抽出The mixture was extracted with dichloromethane (200 ml)
3. 3
   乾燥After the mixture was dried over anhydrous magnesium sulfate
4. 4
   その他the solvent was evaporated

実験手順

Pyridinium p-toluenesulfonate (0.30 g, 0.0012 mol) was added to a solution of 2-bromobenzyl alcohol (25 g, 0.134 mol) in dichloromethane (100 ml), and the mixture was stirred at room temperature. To this mixture was added 3,4-dihydro-2H-pyrane (16.86 g, 0.20 mol). After the resulting mixture was stirred at room temperature for 2 hours, a saturated aqueous solution (200 ml) of sodium bicarbonate was added. The mixture was extracted with dichloromethane (200 ml). After the mixture was dried over anhydrous magnesium sulfate, the solvent was evaporated to obtain the desired compound 1-bromo-2-(2-tetrahydropyranyloxymethyl)benzene (36.00 g, Yield: 99.3%) as an oil.

出典