反応 #429216

反応方程式

methylene chloride

product

1-((6-chloro-1,3-benzodioxol-5-yl)methyl)-4-((4-methoxyphenyl)thio)-2-phenyl-1H-imidazole-5-carboxaldehyde

sodium cyanide

methanol

→

expected product

methyl 1-((6-chloro-1,3-benzodioxol-5-yl)methyl)-4-((4-methoxyphenyl)thio)-2-phenyl-1H-imidazole-5-carboxylate

溶媒

acetic acid

反応条件

実験手順

The operation is carried out as in Example 9 starting with 2 g of the product of Example 20 using 10 g of manganese oxide, 1 g of sodium cyanide, 200 ml of methanol, 40 ml of methylene chloride and 600 ul of acetic acid, in this way 1.64 g of expected product is obtained (M.p.=161° C.).

出典