反応 #429214

反応方程式

methanol

acetic acid

sodium cyanide

product

1-((6-chloro-1,3-benzodioxol-5-yl) methyl)-4-(((4-methoxyphenyl) methyl) thio)-2-phenyl-1H-imidazole-5-carboxaldehyde

→

expected product

methyl 1-((6-chloro-1,3-benzodioxol-5-yl) methyl)-4-(((4-methoxyphenyl) methyl) thio)-2-phenyl-1H-imidazole-5-carboxylate

溶媒

methylene chloride

反応条件

後処理

1. 1
   ろ過by filtering
2. 2
   洗浄washing with ethyl acetate
3. 3
   その他evaporating

実験手順

30 ml of methanol, 120 ul of acetic acid, 2.25 g of manganese oxide and 300 mg of sodium cyanide are added respectively to a solution of 600 mg of the product of Example 7 in methylene chloride. The reaction medium is left under agitation at ambient temperature for 96 hours, followed by filtering, washing with ethyl acetate and evaporating. 410 mg of expected product is obtained M.p.=158° C.

出典