反応 #42811

反応方程式

4-chloro-6-(2-butynyloxy)pyrimidine

3-trifluoromethylpiperidine

→

4-(2-butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine

収率 61.4%

反応条件

実験手順

0.3 g of 4-chloro-6-(2-butynyloxy)pyrimidine and 0.25 g of 3-trifluoromethylpiperidine were mixed and left for 10 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.30 g of 4-(2-butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine (hereinafter, referred to as Compound (24)).

出典