反応 #42799

反応方程式

4-chloro-5-fluoro-6-(2-pentynyloxy)pyrimidine

3-methylpiperidine

→

5-fluoro-4-(3-methylpiperidino)-6-(2-pentynyloxy)pyrimidine

収率 89.0%

反応条件

実験手順

0.2 g of 4-chloro-5-fluoro-6-(2-pentynyloxy)pyrimidine and 0.29 g of 3-methylpiperidine were mixed and left for 3 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.23 g of 5-fluoro-4-(3-methylpiperidino)-6-(2-pentynyloxy)pyrimidine (hereinafter, referred to as Compound (10)).

出典