反応 #42774

反応方程式

3-(4-Chlorophenyl)-7-hydroxy-2-isopropyl-chromen-4-one

N-iodosuccinimide

→

3-(4-Chlorophenyl)-7-hydroxy-8-iodo-2-isopropyl-chromen-4-one

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   洗浄washed with water (3×100 ml) and saturated brine (50 ml)
2. 2
   乾燥dried (MgSO4)
3. 3
   ろ過filtered
4. 4
   その他the filtrate is evaporated
5. 5
   その他to give a pale pink solid

実験手順

3-(4-Chlorophenyl)-7-hydroxy-2-isopropyl-chromen-4-one (2.3 g, 7.31 mmol) is suspended in dry dichloromethane (140 ml) at room temperature. N-iodosuccinimide (1.73 g, 7.67 mmol) is added, and the mixture is stirred vigorously at room temperature for 30 min. The mixture is diluted with dichloromethane (60 ml), washed with water (3×100 ml) and saturated brine (50 ml), dried (MgSO4) and filtered, and the filtrate is evaporated to give a pale pink solid.

出典