反応 #42727

反応方程式

4-hydroxyphenethyl alcohol

potassium carbonate

1,3 dibromopropane

→

title compound

収率 77.3%

2-[4-(3-Bromopropoxy)phenyl]ethanol

収率 77.3%

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度cooled to room temperature
2. 2
   ろ過filtered
3. 3
   濃縮concentrated under vacuum
4. 4
   その他The resulting oil was purified by silica gel chromatography
5. 5
   workup.ADDITIONa mixture of 4:1 hexanes and ethyl acetate

実験手順

To a solution of 4-hydroxyphenethyl alcohol (4.37 g, 31.0 mmol) and potassium carbonate (6.55 g, 47.0 mmol) in acetonitrile (62.0 mL) was added 1,3 dibromopropane (31.0 mL, 316 mmol). The reaction mixture was heated to 70° C. for 12 hours and then cooled to room temperature, filtered and concentrated under vacuum. The resulting oil was purified by silica gel chromatography using a mixture of 4:1 hexanes and ethyl acetate to give the title compound (6.21 g) as a white solid.

出典