反応 #426989

反応方程式

2,6-dichloro-4-trifluoromethylpyridine

NaOH MeOH

→

2-methoxy-6-chloro-4-trifluoromethylpyridine

収率 99.9%

溶媒

methanol

反応条件

後処理

1. 1
   その他at room temperature
2. 2
   その他overnight
3. 3
   抽出The reaction mixture was extracted with pentane
4. 4
   濃縮the extract was concentrated in vacuo

実験手順

To a solution of 2,6-dichloro-4-trifluoromethylpyridine (10 g, 46.3 mmol) in methanol (200 mL) was added 25% NaOH/MeOH (12.5 g, 13.2 mL, 231 mmol), which was then stirred at 50° C. for 2 h and then at room temperature overnight. The reaction mixture was extracted with pentane, and the extract was concentrated in vacuo to afford 2-methoxy-6-chloro-4-trifluoromethylpyridine (9.79 g), used without further purification.

出典