反応 #42693

反応方程式

hydrochloric acid

potassium carbonate

2,3-dichloroquinoxaline

2-chlorobenzenesulfonamide

→

title compound

収率 101.0%

2-chloro-N-(3-chloroquinoxalin-2-yl)benzenesulfonamide

収率 101.0%

溶媒

water

dimethylformamide

反応条件

後処理

1. 1
   抽出extracted with ethyl acetate
2. 2
   洗浄The residue was washed with a saturated aqueous solution of sodium chloride
3. 3
   乾燥dried with anhydrous magnesium sulfate
4. 4
   濃縮concentrated

実験手順

In the presence of potassium carbonate (625 mg), 2,3-dichloroquinoxaline (275 mg) and 2-chlorobenzenesulfonamide (264 mg) were allowed to react in the solution of dimethylformamide (4 mL) for 3 hours at 90° C. To the reaction mixture, water and hydrochloric acid were added and extracted with ethyl acetate. The residue was washed with a saturated aqueous solution of sodium chloride, dried with anhydrous magnesium sulfate and concentrated to obtain the title compound (493 mg) having the following physical data.

出典