反応 #426805

反応方程式

NaHCO3

DHP

CSA

[2-bromo-3-(4-methoxy-benzyloxy)-phenyl]-methanol

→

title compound

2-[2-Bromo-3-(4-methoxy-benzyloxy)-benzyloxy]-tetrahydro-pyran

溶媒

CH2Cl2

反応条件

後処理

1. 1
   workup.ADDITION4 Å Molecular sieves (1.0 g) was added
2. 2
   workup.STIRRINGmixture was stirred for 1 h
3. 3
   抽出mixture was extracted with CHCl3 (2×50 mL)
4. 4
   洗浄The organic fractions were washed with H2O (2×25 mL)
5. 5
   乾燥brine (50 mL), dried (Na2SO4)
6. 6
   濃縮concentrated in vacuo
7. 7
   その他The residue was purified by flash chromatography (25% EtOAc in hexane)

実験手順

DHP (0.67 mL, 7.4 mmol) and CSA (30 mg, 0.12 mmol) were added to a solution of [2-bromo-3-(4-methoxy-benzyloxy)-phenyl]-methanol (2.0 g, 6.1 mmol) in CH2Cl2 (15 mL). The resulting mixture was stirred at rt O/N. 4 Å Molecular sieves (1.0 g) was added and mixture was stirred for 1 h. Sat. NaHCO3 was added and mixture was extracted with CHCl3 (2×50 mL). The organic fractions were washed with H2O (2×25 mL) then brine (50 mL), dried (Na2SO4), and concentrated in vacuo. The residue was purified by flash chromatography (25% EtOAc in hexane) to give the title compound as yellow oil: yield 1.30 g (96%).

出典