反応 #426696

反応方程式

DIAD

2-fluoroethanol

4-hydroxybenzaldehyde

triphenylphosphine

→

4-(2-Fluoroethoxy)benzaldehyde

収率 40.3%

title compound

収率 40.3%

溶媒

THF

反応条件

後処理

1. 1
   その他to rise to room temperature
2. 2
   workup.STIRRINGstirred for 48 h
3. 3
   その他The solvent was removed under reduced pressure
4. 4
   その他the residue was purified by flash chromatography (5:1 DCM/Hexane)

実験手順

To a mixture of 4-hydroxybenzaldehyde (1.45 g, 11.9 mmol), triphenylphosphine (6.87 g, 26.2 mmol) and 2-fluoroethanol (1.68 g, 26.2 mmol) in dry THF (70 ml) at 0° C., was added DIAD (5.29 g, 26.2 mmol) dropwise. The reaction mixture was stirred at 0° C. for 1 h then allowed to rise to room temperature and stirred for 48 h. The solvent was removed under reduced pressure and the residue was purified by flash chromatography (5:1 DCM/Hexane) to give the title compound (0.807 g, 40%) as a colourless solid.

出典