反応 #42615

反応方程式

HCl

ethyl 2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate

lithium hydroxide

tetrahydrofuran

→

2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxylic acid

収率 82.4%

溶媒

water

反応条件

後処理

1. 1
   抽出extracting with ethyl acetate
2. 2
   洗浄The organic layer was washed with water and brine
3. 3
   乾燥dried with magnesium sulfate
4. 4
   その他The solution was then evaporated to dryness

実験手順

To a 50 ml round bottom flask was added (61 mg, 0.2457 mmoles) ethyl 2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate, (51.5 mg, 1.2274 mmoles, 5.0 eq.) lithium hydroxide, (2.5 ml) tetrahydrofuran and (1.5 ml) water. The reaction was agitated at ambient temperature for ˜2 hours. The reaction was complete by electrospray mass spec. The reaction was worked up by adding (5 ml) 1N HCl and then extracting with ethyl acetate. The organic layer was washed with water and brine and then dried with magnesium sulfate. The solution was then evaporated to dryness, leaving (44.6 mg) of 2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxylic acid.

出典