反応 #4259

反応方程式

bromoacetic acid

2,5-dimercapto-1,3,4-thiadiazole

potassium hydroxide

→

desired compound

収率 86.6%

2-Carboxymethylthio-5-Mercapto-1,3,4-Thiadiazole

収率 86.6%

溶媒

water

water

反応条件

後処理

1. 1
   その他dropwise at room temperature
2. 2
   workup.ADDITIONAfter the addition
3. 3
   温度to cool to room temperature
4. 4
   ろ過The precipitated crystals were filtered
5. 5
   洗浄washed with water

実験手順

In 200 ml of water were dissolved 15.0 g of 2,5-dimercapto-1,3,4-thiadiazole and 69 g of potassium hydroxide, and a solution of 13.9 g of bromoacetic acid in 30 ml of water was added thereto dropwise at room temperature. After the addition, the mixture was stirred at 60° C. for 1 hour, followed by allowing to cool to room temperature. The precipitated crystals were filtered and washed with water to obtain 18 g of the desired compound. Melting point: 161°-167° C.

出典