反応 #42499

反応方程式

Methyl 1H-indole-6-carboxylate

potassium tert-butoxide

Iodobutane

→

methyl 1-butyl-1H-indole-6-carboxylate

溶媒

DMSO

反応条件

後処理

1. 1
   workup.STIRRINGto stir for three additional hours
2. 2
   その他The mixture was partitioned between ethyl acetate and water and brine
3. 3
   乾燥dried over sodium sulfate
4. 4
   ろ過filtered
5. 5
   濃縮concentrated

実験手順

Methyl 1H-indole-6-carboxylate (4.17 g) was dissolved in DMSO (30 mL), and potassium tert-butoxide (2.93 g) was added. The mixture was stirred for ten min at room temperature. Iodobutane (3.0 mL) was added. The mixture was allowed to stir for three additional hours. The mixture was partitioned between ethyl acetate and water and brine, dried over sodium sulfate, filtered, and concentrated to give methyl 1-butyl-1H-indole-6-carboxylate (4.53 g). MS (ESI+) for C14H17NO2+H1 m/z 232.12 (M+H)+.

出典