反応 #424800

反応方程式

1-bromo-2-methoxyethane

4-chloro-3-methylphenol

K2CO3

→

title compound

1-Chloro-4-(2-methoxyethoxy)-2-methylbenzene

溶媒

water

ether

DMF

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他The organic phase was separated
3. 3
   洗浄washed sequentially with 2 N aq. NaOH, water and brine
4. 4
   抽出The organic extract
5. 5
   乾燥was dried over Na2SO4
6. 6
   ろ過filtered
7. 7
   濃縮the filtrate concentrated in vacuo

実験手順

To a stirred solution of 4-chloro-3-methylphenol (1 eq.) in DMF (0.7 M) was added K2CO3 (1.2 eq.). The mixture was stirred at 50° C. for 5 min before 1-bromo-2-methoxyethane (1.5 eq.) was added. After 2 h at 70° C., the reaction mixture was cooled down to RT and then diluted with water and ether. The organic phase was separated and washed sequentially with 2 N aq. NaOH, water and brine. The organic extract was dried over Na2SO4, filtered and the filtrate concentrated in vacuo to afford the title compound as a yellowish oil.

出典