反応 #4239

反応方程式

2-(chloromethyl)benzenesulfonamide

pyrrolidine

→

white solid

収率 92.8%

2-(1-Pyrrolidinylmethyl)benzenesulfonamide

収率 92.8%

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他the volatiles were removed under vacuum
2. 2
   workup.ADDITIONthe residue was treated with water (40 ml)
3. 3
   温度chilled
4. 4
   ろ過filtered
5. 5
   その他dried

実験手順

A solution of 2-(chloromethyl)benzenesulfonamide (2.00 g, 10 mmol) in acetonitrile (20 ml) was contacted with pyrrolidine (1.6 ml, 20 mmol). After 1.0 hr at ambient temperature, the volatiles were removed under vacuum and the residue was treated with water (40 ml) and chilled. The resulting solid was pulverized, filtered, and dried to give 2.23 g of white solid, m.p. 110°-112°.

出典