反応 #4228

反応方程式

2,6-dimethoxy-5-nitro-4-pyrimidinamine

2-carbomethoxybenzenesulfonyl isocyanate

→

title compound

収率 90.6%

2-[[(2,6-Dimethoxy-5-nitropyrimidin-4-yl)aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester

収率 90.6%

溶媒

methylene chloride

反応条件

後処理

1. 1
   その他The solvent was then evaporated under reduced pressure
2. 2
   ろ過The solid was then collected by filtration
3. 3
   洗浄washed with ether
4. 4
   その他dried in an oven

実験手順

A solution of 0.2 g (1.0 mmol) of 2,6-dimethoxy-5-nitro-4-pyrimidinamine and 0.6 g (2.4 mmol) of 2-carbomethoxybenzenesulfonyl isocyanate in 15 ml of methylene chloride was stirred at ambient temperature and pressure for 12 hours under anhydrous conditions. The solvent was then evaporated under reduced pressure. The residue was stirred in n-butyl chloride (70 ml). The solid was then collected by filtration, washed with ether and then dried in an oven to afford 0.4 g of the title compound, m.p. 150°-152° dec.

出典