反応 #4227

反応方程式

sulfuric acid

2,6-dimethoxy-4-pyrimidinamine

nitric acid

→

title compound

2,6-Dimethoxy-5-nitro-4-pyrimidinamine

反応条件

後処理

1. 1
   workup.WAITpressure for thirty minutes
2. 2
   workup.STIRRINGwas then stirred at 50° for fifteen minutes
3. 3
   温度The solution was then cooled in an ice bath to ~0° C
4. 4
   ろ過The solid was collected by filtration
5. 5
   洗浄washed with water
6. 6
   その他dried in an oven at 60° C.

実験手順

To a solution of 20 ml of concentrated nitric acid and 16 ml of concentrated sulfuric acid was added 3.9 g (0.025 mmol) of 2,6-dimethoxy-4-pyrimidinamine. The resulting solution was stirred at ambient temperature and pressure for thirty minutes and was then stirred at 50° for fifteen minutes. The solution was then cooled in an ice bath to ~0° C. The solid was collected by filtration, washed with water and dried in an oven at 60° C. to afford 3.6 g of the title compound, m.p. 178°-179° C.

出典