反応 #422520
ord-34fd010f8bc54a47a5e1bf413d84d817
反応方程式
6-methyl-5-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamido)nicotinic acid
6-Methyl-5-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamido)nicotinic Acid
Intermediate 1C
methyl 5-(7-bromoimidazo[1,2-a]pyridine-3-carboxamido)-6-methylnicotinate
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole
sodium hydroxide
→
反応物
6-methyl-5-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamido)nicotinic acid
6-Methyl-5-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamido)nicotinic Acid
Intermediate 1C
methyl 5-(7-bromoimidazo[1,2-a]pyridine-3-carboxamido)-6-methylnicotinate
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole
—
methyl ester
sodium hydroxide
試薬
なし
反応条件
詳細条件
See reaction.notes.procedure_details.
実験手順
The title compound was prepared analogously to 6-methyl-5-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamido)nicotinic acid (Example 9.0 step 2) from Intermediate 1C and 1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole followed hydrolysis of the resulting methyl ester using sodium hydroxide;