反応 #4209

反応方程式

2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

sodium iodide

→

title compound

収率 60.4%

2-Iodo-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

収率 60.4%

溶媒

acetone

反応条件

後処理

1. 1
   ろ過The reaction was filtered hot
2. 2
   その他to remove the sodium iodide
3. 3
   その他a precipitate formed in the cold filtrate which
4. 4
   その他was collected
5. 5
   洗浄washed with cold acetone
6. 6
   その他to give
7. 7
   その他upon drying

実験手順

A solution of 2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide (8.98 g, 23.5 mmol) and sodium iodide (3.53 g, 23.5 mmol) in acetone (75 ml) was refluxed for two hours and allowed to stand overnight at room temperature. The reaction was filtered hot to remove the sodium iodide and a precipitate formed in the cold filtrate which was collected and washed with cold acetone to give, upon drying, 6.71 g (14.2 mmol) of the title compound. A second crop was obtained from cold acetone (1.0 g).

出典