反応 #42041

反応方程式

3-fluoromethyl-4-(1-methylpiperidin-4-ylmethyl)benzoic acid

thionyl chloride

→

3-fluoromethyl-4-(1-methylpiperidin-4-ylmethyl)benzoyl chloride hydrochloride

反応条件

後処理

1. 1
   その他obtained in the step 7
2. 2
   workup.DISTILLATIONwas distilled off under reduced pressure
3. 3
   workup.ADDITIONthe operation of adding of toluene to the residue
4. 4
   その他followed by azeotropic removal of thionyl chloride

実験手順

This compound was prepared in the same manner as in Reference Example 1 (step 7), except that 3-fluoromethyl-4-(1-methylpiperidin-4-ylmethyl)benzoic acid obtained in the step 7 was used, and that treatment after the reaction was that thionyl chloride was distilled off under reduced pressure, and then the operation of adding of toluene to the residue, followed by azeotropic removal of thionyl chloride was repeated twice.

出典