反応 #42040

反応方程式

t-butyl 3-difluoromethyl-4-(4-methylpiperazin-1-ylmethyl)benzoate

→

3-difluoromethyl-4-(4-methylpiperazin-1-ylmethyl)benzoic acid

溶媒

methanol

反応条件

後処理

1. 1
   その他obtained in the step 5
2. 2
   その他were removed by filtration
3. 3
   workup.DISTILLATIONthe filtrate was distilled off under reduced pressure
4. 4
   その他the residue was crystallized from acetonitrile

実験手順

This compound was prepared in the same manner as in Reference Example 1 (step 6), except that t-butyl 3-difluoromethyl-4-(4-methylpiperazin-1-ylmethyl)benzoate obtained in the step 5 was used, and that the resulting crude product was mixed with methanol, insolubles were removed by filtration, the filtrate was distilled off under reduced pressure, and then the residue was crystallized from acetonitrile.

出典