反応 #41997

反応方程式

N-{3-[5-fluoro-1-(3-iodo-propyl)-indan-1-yl]-1H-indol-7-yl}-methane sulfonamide

methylamine

→

title compound

収率 49.0%

N-{3-[5-Fluoro-1-(3-methylamino-propyl)-indan-1-yl]-1H-indol-7-yl}-methanesulfonamide

収率 49.0%

溶媒

tetrahydrofuran

dichloromethane

potassium carbonate

反応条件

後処理

1. 1
   ろ過Filter the white solids
2. 2
   その他that crush out and
3. 3
   その他dry under high vacuum

実験手順

Stir N-{3-[5-fluoro-1-(3-iodo-propyl)-indan-1-yl]-1H-indol-7-yl}-methane sulfonamide (88 mg, 0.17 mmol) and methylamine (40% in water, 2 ml) in tetrahydrofuran (1 ml) at room temperature under nitrogen for 30 minutes. Dilute with dichloromethane and 10% aqueous potassium carbonate. Filter the white solids that crush out and dry under high vacuum to obtain the title compound (35 mg, 49%). LC-MS m/z 416.1 (M++1).

出典