反応 #41967

反応方程式

5-fluoro-indan-1-one

pyrazole

potassium carbonate

→

title compound

収率 73.0%

5-Pyrazol-1-yl-indan-1-one

収率 73.0%

溶媒

dimethyl sulfoxide

ether

反応条件

後処理

1. 1
   洗浄wash with water (2×)
2. 2
   乾燥dry over anhydrous sodium sulfate
3. 3
   濃縮concentrate

実験手順

Combine 5-fluoro-indan-1-one (1.02 g, 6.79 mmol), pyrazole (0.46 g, 6.79 mmol), and potassium carbonate (1.03 g, 7.47 mmol, 1.10 equivalents) in dimethyl sulfoxide (5 ml) in a sealed tube and heat to 100° C. for 48 hours. Cool to room temperature, dilute with ether, wash with water (2×), dry over anhydrous sodium sulfate, and concentrate to obtain the title compound as a brown solid (0.98 g, 73%). LC-MS m/z 199.1 (M++1).

出典