反応 #41965

反応方程式

triphenylphosphine

3-bromopropionic acid

ether

→

title compound

収率 68.5%

(2-Carboxy-ethyl)-triphenyl-phosphonium bromide

収率 68.5%

溶媒

acetonitrile

反応条件

後処理

1. 1
   ろ過Filter solids
2. 2
   洗浄rinse with ether
3. 3
   その他dry solids under high vacuum

実験手順

Reflux a solution of triphenylphosphine (91.3 g, 348 mmol, 1.05 equivalents) and 3-bromopropionic acid (50.7 g, 331 mmol) in acetonitrile (250 ml) for three hours, allow to sit at room temperature overnight. Add ether (400 ml) and cool in the freezer for two hours. Filter solids, rinse with ether, and dry solids under high vacuum to obtain the title compound (94.1 g, 68%). NMR (400 MHz, CDCl3): δ 3.15 (m, 2H), 3.73 (m, 2H), 7.69-7.83 (m, 15H).

出典