反応 #41957

反応方程式

Chloroacetaldehyde diethyl acetal

benzoic acid

potassium iodide

potassium carbonate

→

compound

収率 56.0%

2-benzoyloxyacetaldehyde Diethyl Acetal

収率 56.0%

溶媒

DMF

ethyl acetate

water

反応条件

後処理

1. 1
   温度by refluxing
2. 2
   ろ過After filtration
3. 3
   その他the organic layer was separated
4. 4
   濃縮was subjected to vacuum concentration

実験手順

Chloroacetaldehyde diethyl acetal (2.00 g), benzoic acid (2.16 g), potassium iodide (0.27 g), potassium carbonate (1.11 g) and DMF (20 mL) were placed in a three-neck flask, followed by refluxing. Twenty hours later, the reaction mixture was cooled to room temperature, and water (30 mL) and ethyl acetate (80 mL) were added thereto, followed by stirring. After filtration, the organic layer was separated, was subjected to vacuum concentration and thereby yielded the target compound (1.74 g) in a yield of 56%.

出典