反応 #41808

反応方程式

hexane EtOAc

3-phenoxyaniline

thiophosgene

→

3-phenoxyphenylisothiocyanate

溶媒

acetone

反応条件

後処理

1. 1
   その他the resulting reaction
2. 2
   温度maintained for 30 min
3. 3
   濃縮The reaction was concentrated
4. 4
   その他azeotroped with toluene
5. 5
   その他taken on without further purification

実験手順

To a stirring solution of 3-phenoxyaniline (185 mg, 1.0 mmol) in acetone (4.0 mL) at 0° C. was added thiophosgene (0.23 mL, 3.0 mmol) and the resulting reaction maintained for 30 min. The reaction determined complete by TLC (4:1 hexane/EtOAc). The reaction was concentrated, azeotroped with toluene and taken on without further purification.

出典