反応 #417972

反応方程式

Water

compound 26a

2-(3-bromo-propoxy)-1-chloro-4-nitro benzene

N-phenyl piperazine

potassium carbonate

→

title compound 26b

収率 78.0%

1-[3-(2-chloro-5-nitro-phenoxy)-propyl]-4-phenyl-piperazine

収率 78.0%

溶媒

DMF

反応条件

後処理

1. 1
   その他at room temperature
2. 2
   抽出extracted with ethyl acetate (3×20 mL)
3. 3
   乾燥The combined extracts were dried over sodium sulfate
4. 4
   濃縮concentrated under reduced pressure
5. 5
   その他The crude product was purified by flash column chromatography

実験手順

To the compound 26a (2.1 g, 7.1 mmol) in DMF (9 mL) was added N-phenyl piperazine (1.16 g, 7.1 mmol) and potassium carbonate (1.28 g, 9.23 mmol). The mixture was stirred for 18 hrs. at room temperature. Water (10 mL) was added to the reaction mixture and extracted with ethyl acetate (3×20 mL). The combined extracts were dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by flash column chromatography to get the title compound 26b in 78% yield as yellow solid.

出典