反応 #417969

反応方程式

BBr3

1-bromo-2-methoxy-4-nitrobenzene

→

desired compound

収率 65.0%

2-bromo-5-nitro-phenol

収率 65.0%

溶媒

DCM

反応条件

後処理

1. 1
   その他The mixture was quenched with water
2. 2
   抽出extracted with ethyl acetate (3×20 mL)
3. 3
   その他The combined extracts were dried
4. 4
   その他the crude was purified by flash column chromatography

実験手順

BBr3 (8.58 mL of 1.0M solution, 8.6 mmol) was added to the DCM (10 mL) solution of 1-bromo-2-methoxy-4-nitrobenzene (1.0 g, 4.3 mmol) at 0° C. The reaction mixture was warmed to room temperature and stirred overnight. The mixture was quenched with water and extracted with ethyl acetate (3×20 mL). The combined extracts were dried and the crude was purified by flash column chromatography to get the desired compound as pale brown powder in 65% yield (600 mg).

出典