反応 #417964

反応方程式

Acetic anhydride

4-chloro-3-hydroxy aniline

→

product 17a

収率 93.0%

N-(4-chloro-3-hydroxyphenyl)acetamide

収率 93.0%

溶媒

acetic acid

反応条件

後処理

1. 1
   温度the reaction was refluxed for 5 mins
2. 2
   ろ過It was filtered off
3. 3
   洗浄washed with water (10 mL)
4. 4
   その他dried

実験手順

Acetic anhydride (3.0 mL, 42.0 mmol) was added to a solution of 4-chloro-3-hydroxy aniline (4.0 g, 28 mmol) in acetic acid (20 mL), and the reaction was refluxed for 5 mins. The reaction mixture was cooled to room temperature and the product was solidified. It was filtered off and washed with water (10 mL) and dried to obtain the product 17a in 93% yield (4.8 g) as a creamy white solid. There was no need for further purification.

出典