反応 #417952

反応方程式

dimethyl sulfone

sodium-bis-(trimethylsilyl)-amide

THF

2-bromo-6-fluoropyridine

→

2-Bromo-6-(1-methanesulfonyl-cyclopropyl)-pyridine

反応条件

後処理

1. 1
   その他The reaction is quenched by the addition
2. 2
   抽出NaCl solution and extracted with EtOAc
3. 3
   乾燥The organic layer is dried over MgSO4
4. 4
   ろ過filtered
5. 5
   その他the solvent is removed in vacuo

実験手順

Under inert gas atmosphere 28.4 mL (56.8 mmol) of a sodium-bis-(trimethylsilyl)-amide solution in THF (c=2 mol/L) are chilled to −17° C. and dropwise charged with 2.00 g (11.3 mmol) 2-bromo-6-fluoropyridine. Afterwards 2.14 g (22.7 mmol) dimethyl sulfone are added and the reaction mixture is stirred at −17° C. for 1 h. The reaction is quenched by the addition of aq. sat.NaCl solution and extracted with EtOAc. The organic layer is dried over MgSO4, filtered and the solvent is removed in vacuo.

出典