反応 #417951

反応方程式

4-bromo-5-fluoro-pyridin-2-ol

ethyliodide

→

4-Bromo-2-ethoxy-5-fluoro-pyridine

溶媒

DCM

反応条件

後処理

1. 1
   その他The reaction is quenched by the addition of water
2. 2
   workup.ADDITIONDCM is added
3. 3
   ろ過the resulting mixture is filtered
4. 4
   乾燥dried over MgSO4
5. 5
   ろ過filtered again
6. 6
   その他the solvent is removed in vacuo

実験手順

0.20 g (1.04 mmol) 4-bromo-5-fluoro-pyridin-2-ol, 0.83 mL (10.4 mmol) ethyliodide and 0.43 g (1.56 mmol) Ag2CO3 are added to 5 mL DCM and stirred at r.t. over night. The reaction is quenched by the addition of water. DCM is added, the resulting mixture is filtered and the organic layer is separted, dried over MgSO4, filtered again and the solvent is removed in vacuo.

出典