反応 #417943

反応方程式

(S)-1-(4-bromophenyl)ethylamine

acetic anhydride

→

(S)—N-(1-(4-Bromophenyl)ethyl)acetamide

溶媒

DCM

反応条件

後処理

1. 1
   その他Then the cooling is removed
2. 2
   洗浄Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water
3. 3
   乾燥layer is dried over MgSO4
4. 4
   ろ過filtered
5. 5
   その他the solvent is removed in vacuo

実験手順

To 200 g (1.00 mol) (S)-1-(4-bromophenyl)ethylamine in 800 mL DCM are slowly added 94.5 mL (1.00 mol) acetic anhydride while cooling the mixture to 20-30° C. Then the cooling is removed and the reaction mixture is stirred at r.t. over night. Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water. The org. layer is dried over MgSO4, filtered and the solvent is removed in vacuo.

出典