反応 #417922

反応方程式

sodium hydroxide

25

methyl 3-(undec-4-ynyloxy)benzoate

→

pale yellow oil

収率 99.4%

3-(undec-4-ynyloxy)benzoic acid

収率 99.4%

溶媒

methanol

反応条件

後処理

1. 1
   温度The solution is refluxed for 1 hour 30 minutes
2. 2
   その他After evaporating off the solvent
3. 3
   抽出extracted with DCM

実験手順

300 μL of 1 N sodium hydroxide solution (300 μmol) are added portionwise to 48 mg of 25 (157 μmol) in methanol (2 mL). The solution is refluxed for 1 hour 30 minutes. After evaporating off the solvent, the reaction medium is acidified with 0.5 N HCl and extracted with DCM. 45 mg of a pale yellow oil are obtained, i.e. a yield of 99%.

出典