反応 #417917
ord-22aaffe062774d3e82cefa2a869d2bda
反応方程式
(S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine
naphthalene
→
(3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine
反応条件
詳細条件
See reaction.notes.procedure_details.
実験手順
contacting the (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine with an activated naphthalene in a reaction mixture under conditions sufficient to produce (3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine (Duloxetine) having the structure of formula (VIII); and (e) recovering the (3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine from the reaction mixture.