反応 #417709

反応方程式

ethylene glycol

p-toluene sulfonic acid

→

cetal

溶媒

benzene

反応条件

後処理

1. 1
   その他The synthesis of starting materials (1)-(3)
2. 2
   温度were refluxed overnight with a Dean-Stark
3. 3
   その他After evaporation of the solvent and separation on a silica gel column

実験手順

The synthesis of starting materials (1)-(3) is known in the art. To prepare the next intermediate, (4), 9 g (44 mmol) of (3), 20 ml of ethylene glycol, 100 ml of benzene and 3 mg of p-toluene sulfonic acid were refluxed overnight with a Dean-Stark. After evaporation of the solvent and separation on a silica gel column, 9.2 g of the cetal (4) were obtained.

出典