反応 #41769

反応方程式

iodomethane

N-methylcarboxamide

3-isothiocyanatobenzoic acid

→

benzoic acid

溶媒

methanol

反応条件

後処理

1. 1
   濃縮concentrated the solvent
2. 2
   その他purified on silica gel

実験手順

To 4-[3-amino-4-(methylamino)phenoxy](2-pyridyl)}-N-methylcarboxamide (1 eq) in methanol was added 3-isothiocyanatobenzoic acid (1 eq) and stirred at 60° C. for 3 h. To it was then added iodomethane (1 eq) and heated to 60° C. for 3 h and concentrated the solvent and purified on silica gel to yield 3-({1-methyl-5-[2-(N-methylcarbamoyl)(4-pyridyloxy))]benzimidazol-2-yl}amino)benzoic acid. MS: MH+=417.

出典