反応 #417581

反応方程式

2-chloroethyl-4-nitrophenylsulfone

→

1-methyl-N-[2-[(4-nitrophenyl)sulfonyl]ethyl]ethanamine

溶媒

isopropylamine

反応条件

後処理

1. 1
   その他The isopropylamine is removed by evaporation
2. 2
   workup.DISSOLUTIONthe residue is dissolved with agitation in a mixture of methylene chloride and dilute sodium hydroxide
3. 3
   抽出The methylene chloride layer is extracted with dilute sodium hydroxide
4. 4
   乾燥dried over magnesium sulfate
5. 5
   その他The solvent is removed by evaporation

実験手順

A solution of 2-chloroethyl-4-nitrophenylsulfone in isopropylamine is stirred at room temperature for about 72 hr. The isopropylamine is removed by evaporation, and the residue is dissolved with agitation in a mixture of methylene chloride and dilute sodium hydroxide. The methylene chloride layer is extracted with dilute sodium hydroxide, and dried over magnesium sulfate. The solvent is removed by evaporation to give 1-methyl-N-[2-[(4-nitrophenyl)sulfonyl]ethyl]ethanamine as an oil.

出典