反応 #41733

反応方程式

2-chloro-5-methoxybenzoxazole

4-bromoaniline

diisopropylethylamine

→

(4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine

溶媒

dimethylformamide

反応条件

後処理

1. 1
   濃縮The resultant mixture was concentrated
2. 2
   その他partitioned between ethyl acetate and water
3. 3
   洗浄The organic layer was washed with brine
4. 4
   その他dried
5. 5
   その他Purification on silica gel

実験手順

The mixture containing 2-chloro-5-methoxybenzoxazole (1 eq), 4-bromoaniline (2 eq) and diisopropylethylamine was refluxed in dimethylformamide. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave (4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine. MS: MH+=318

出典